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  • Billige Toms Sko

    わたなべ

    2015年9月1日
    Billige Toms Sko

    We plan to use reverse genetics to complement our forward screens. Synapse formation has been highly conserved through evolution [6]. Individual synaptic genes show 70+% identity between Drosophila and higher vertebrates and their functional roles appears highly similar [6]. We will continue with the reverse genetic approach of isolating Drosophila homologues of important synaptic genes and then mutating them to examine their functional role in synaptic transmission. In the past, we have focussed on genes playing roles in neurotransmission (see Projects on Synapse Function). We propose to expand our studies to include genes implicated in synapse formation mechanisms (see above). As previously, we will focus our energy on the phenotypic description of mutant defects using functional and anatomical studies at the embryonic NMJ.

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